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Abstract

Fortified milk containing Lactobacillus plantarum, L. casei, and L. acidophilus isolates and their mixture were used in dosing the male albino rats at an age of 9-12 weeks at an average of 23 g with induced hypothyroidism at a concentration of 0.6 g.kg-1 of carbimazole. Total cholesterol, triglycerides, high-density lipoprotein (HDL), low-density lipoprotein (LDL), and very-low-density lipoprotein (VLDL) were estimated. The results showed a significant increase in the level of triglycerides (TG), cholesterol and triglycerides. Low-density lipoprotein (LDL) and very-low-density lipoprotein (VLDL), with a significant decrease in the level of high-density lipoprotein (HDL) in infected male mice, compared to the control sample, and upon dosing with liquid milk fortified, it returned to its normal level without significant differences from the control group.

Keywords

Carbimazole Lactic acid bacteria Hypothyroidism

Article Details

How to Cite
Nasser, E. K. . ., Majeed , K. R. ., & Ali , H. I. . (2021). Effect of Some Strains of Lactic Acid Bacteria and Their Mixture on the Level of Fats and Cholesterol in Albino Rats (Rattus norvegicus) Male with Hypothyroidism Induced Using Carbimazole. Basrah J. Agric. Sci., 34(1), 139–146. https://doi.org/10.37077/25200860.2021.34.1.12

References

  1. Abbas, J. M., Chakraborty, J., Akanji, A. O., & Doi, S. A. (2008). Hypothyroidism results in small dense LDL independent of IRS traits and hypertriglyceridemia. Endocrine Journal, 55, 381-389.‏ https://www.jstage.jst.go.jp/article/endocrj/55/2/55_K07E-065/_pdf
  2. Abdullah, Kh. Sh., Salih, H. M. & Mohammed, N. F. (2013). The impact of the yoghurt product by using the lactic acid bacteria (ABT) in reducing the level of lioid profil in blood of rats and incrase weights. Tikrit University Journal of Agricultural Sciences, 13, 14-22. https://www.iasj.net/iasj/download/8c9fd82dfb389dda
  3. Bartley, G. E., Yokoyama, W., Young, S. A., Anderson, W. H., Hung, S. C., Albers, D. R., & Kim, H. (2010). Hypocholesterolemic effects of hydroxypropyl methylcellulose are mediated by altered gene expression in hepatic bile and cholesterol pathways of male hamsters. Journal of Nutrition, 140, 1255-1260. https://doi.org/10.3945/jn.109.118349
  4. Burtis, C. A., Ashwood, E. R., & Bruns, D. E. (2012). Tietz textbook of clinical chemistry and molecular diagnostics-e-book. Elsevier Health Sciences. https://pdfs.semanticscholar.org/3834/df7822925163007478abdb6b0ca39af0d2a9.pdf
  5. Ding, W., Shi, C., Chen, M., Zhou, J., Long, R., & Guo, X. (2017). Screening for lactic acid bacteria in traditional fermented Tibetan yak milk and evaluating their probiotic and cholesterol-lowering potentials in rats fed a high-cholesterol diet. Journal of Functional Foods, 32, 324-332.‏ https://doi.org/10.1016/j.jff.2017.03.021
  6. El-Shafie, H. A., Yahia, N. I., Ali, H. A., Khalil, F. A., El-Kady, E. M., & Moustafa, Y. A. (2009). Hypocholesterolemic action of Lactobacillus plantarum NRRL-B-4524 and Lactobacillus paracasei in ratswith hypercholesterolemia induced by diet. Australian Journal of Basic and Applied Sciences, 3, 218-228. https://www.researchgate.net/profile/Ebtsam_El-kady/publication/344291389_Hypocholesterolemic_Action_of_Lactobacillus_plantarum_NRRL-B-4524_and_Lactobacillus_paracasei_in_Mice_with_Hypercholesterolemia_Induced_by_Diet/links/55dd86ab08ae83e420ee75af/Hypocholesterolemic-Action-of-Lactobacillus-plantarum-NRRL-B-4524-and-Lactobacillus-paracasei-in-Mice-with-Hypercholesterolemia-Induced-by-Diet.pdf.
  7. Gaudana, S. B.,Dhanani, A. S., & Bagchi, T. (2010). Probiotic attributes of Lactobacillus strains isolated from food and of human origin. British Journal of Nutrition, 103, 1620-1628. DOI: 10.1017/S0007114509993643. Epub 2010 Jan 14.
  8. Kalender, S., Uzun, F. G., Durak, D., Demir, F., & Kalender, Y. (2010). Malathion-induced hepatotoxicity in rats: the effects of vitamins C and E. Food and Chemical Toxicology, 48, 633-638.‏ https://doi.org/10.1016/j.fct.2009.11.044
  9. Kumar, M., Nagpal, R., Kumar, R., Hemalatha, R., Verma, V. Kumar, A., Chakraborty, C., Singh, B., Marotta, F., Jain, S., & Yaday. H. (2012). Cholesterol-lowering probiotics as potential biotherapeutics for metabolic diseases. Experimental Diabetes Research, 2012, 902917, 14pp. https://doi.org/10.1155/2012/902917
  10. Ma, C., Zhang, S., Lu, J., Zhang, C., Pang, X., & Lv, J. (2019). Screening for cholesterol-lowering probiotics from lactic acid bacteria isolated from corn silage based on three hypothesized pathways. International Journal of Molecular Sciences, 20, 2073.‏ https://doi.org/10.3390/ijms20092073
  11. Nichols, M., Townsend, N., Scarborough, P., & Rayner, M. (2013). Cardiovascular disease in Europe: epidemiological update. European Heart Journal, 34, 3028-3034.‏ https://doi.org/10.1093/eurheartj/eht356
  12. Pavli, F., Tassou, C., Nychas, G. J. E., & Chorianopoulos, N. (2018). Probiotic incorporation in edible films and coatings: Bioactive solution for functional foods. International Journal of Molecular Sciences, 19, 150.‏ DOI: 10.3390/ijms19010150
  13. Reeves, P. G. (1996). AIN-93 purified diets for the study of trace element metabolism in rodents (Vol. 1, pp. 3-37). Boca Raton, FL: CRC Press. https://books.google.iq/books?hl=ar&lr&id=z1ChNSAeVekC&oi=fnd&pg=PA3&dq=AIN+93+(1995)+method&ots=4y62n-pTmp&sig=06fQDHnKkTwjdrYcOGQkrngEFa4&redir_esc=y&pli=1#v=onepage&q=AIN%2093%20(1995)%20method&f=false
  14. SAS (1990). SAS User’s Guide, Statistics, Cary, NC, SAS Institute.
  15. Saxena, S., Funk, M., & Chisholm, D. (2013). World health assembly adopts a comprehensive mental health action plan 2013–2020. The Lancet, 381, 1970-1971. https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(13)61139-3/fulltext
  16. Wang, C. Y., Wu, S. C., Ng, C. C., & Shyu, Y. T. (2010). Effect of Lactobacillus-fermented adlay-based milk on lipid metabolism of hamsters fed a cholesterol-enriched diet. Food Research International, 43, 819-824.‏ https://doi.org/10.1016/j.foodres.2009.11.020