Main Article Content
Abstract
Cordia myxa L. is one of the medical plants that plays an important role in the treatment of many diseases. There are many studies explained that C. myxa can show anti-inflammatory, anti-diabetic, antiparasitic, antimicrobial and immunomodulatory properties. This review was focused on the active compounds and medical effects of C. myxa. The fatty acids contents are particularly high (9.9%). Sodium and potassium constitute the largest mineral proportion (13 ppm and 29 ppm respectively) of the fruit. However, the toxic heavy metals such as lead, cadmium, chromium and copper have not been found in the fruit. This gives an additional significant benefit of the medical uses of the plant. The content of alkaloids, saponin, polyphenols, and comarine were recorded and was relatively high compared to steroids, resins, glycosides, tannins, and gum that found to be in less amounts. When the mucilage was extracted, the alkaloids constitute more than 35%. By using the Folin‐Ciocalteu, C. myxa extracts have a high Phenolic content. The antibacterial activity against gram-negative bacteria were included in the fruit mucilage extract while the alcoholic extracts have no effect on all bacterial isolates. In addition, the mucilage extract showed anti-parasitic activity when it was tested against Leishmania infantum promastigotes. However, the highest concentration of extract significantly reduced the amounts of lymphocytes. Moreover, ethanolic extracts of C. myxa fruits give rise to leucocyte and lymphocyte count. Future research needs to be done on this kind of herbs which could show high medicinal activity.
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References
- Abdallah, I. Z., Khattab, A., & Heeba, H., (2011). Gastroprotective effect of Cordia myxa L. fruit extract against indomethacin-induced gastric ulceration in rats, Life Science Journal, 8(3), 433-445.
- Abdel-Aleem, E. R., Attia, E. Z., Farag, F. F., Samy, M. N., & Desoukey, S. Y. (2019). Total phenolic and flavonoid contents and antioxidant, anti-inflammatory, analgesic, antipyretic and antidiabetic activities of Cordia myxa L. leaves. Clinical Phytoscience, 5, 29. https://doi.org/10.1186/s40816-019-0125-z
- Aberoumand, A., (2011). Preliminary evaluation of some phytochemical and nutrients constituents of Iranian Cordia myxa fruits, International Journal of Agricultural and Food Science. 1(2), 3033. https://www.semanticscholar.org/paper/Preliminary-Evaluation-of-Some-Phytochemical-and-of-Aberoumand/c84ddb97518ee231a07e7489efe704d95fae68bb
- Aberoumand, A., Deokule, S. S., (2008). Comparison of phenolic compounds of some edible plants of Iran and India. Pakistan Journal of Nutrition, 7, 582-585. https://doi.org/10.3923/pjn.2008.582.585
- Aberoumand, A., & Deokule, S. S. (2010). Screening of some nutrients and anti-nutrients components in some plant foods of Iran and India. Journal of Agricultural Technology, 6, 777-781.
- Aimey, Z., Goldson-Barnaby, A, & Bailey, D., (2020). A review of Cordia species found in the Caribbean: Cordia obliqua Willd, Cordia dichotoma G. Forst. and Cordia collococca L. International Journal of Fruit Science, 20, S884-S893. https://doi.org/10.1080/15538362.2020.1772181
- Al-Hamdani, M. S., & Al-Faraji, A. S., (2017). Evaluation of inhibitory activity of Cordia myxa fruit extract on microorganisms that causes spoilage of food and its role in the treatment of certain disease states. Journal of Biology, Agriculture and Healthcare, 7(2), 43-49.
- Ali, K. A. (2008). Study of effect of alcoholic extract of fruit of Cordia myxa in total count and differential count of white blood cells in rats. Al-Qadisyia Journal of Veterinary Medicine Sciences, 7(2), 7, 21-24. https://qmeds.iraqjournals.com/article_33763.html
- Aljeboury, G. H. (2021). Anti-Inflammatory effect of Cordia myxa extract on bacteria that Infected wounds in rats as a model for human. Annals of the Romanian Society for Cell Biology, 25(4), 16040-16045. https://www.annalsofrscb.ro/index.php/journal/article/view/5345
- Al-Musayeib, N., Perveen, S., Fatima, I., Nasir, M., & Hussain, A., (2011). Molecules Antioxidant, Anti-lycation and Anti-inflammatory activities of phenolic constituents from Cordia sinensis. Molecules, 16, 10214-10226. https://doi.org/10.3390/molecules161210214
- Al-Snafi, A. E., (2016). The Pharmacological and therapeutic importance of Cordia myxa- A review. IOSR Journal of Pharmacy, 6, 4757.
- Arbonnier, M., (2000). [Trees, shrubs and lianas of the dry zones of West Africa France]. Montpellier: CIRAD; MNHN. 544pp. (In French) http://publications.cirad.fr/une_notice.php?dk=476380
- Ayoub, Z., & Mehta, A. (2018). Medicinal plants as potential source of antioxidant agents: a review. Asian Journal of Pharmaceutical and Clinical Research, 11(6), 50-56. http://dx.doi.org/10.22159/ajpcr.2018.v11i6.24725
- Anand, U., Jacobo-Herrera, N., Altemimi, A., & Lakhssassi, N. (2019). A comprehensive review on medicinal plants as antimicrobial therapeutics: Potential avenues of biocompatible drug discovery. Metabolites, 9(11), 258. https://doi.org/10.3390/metabo9110258
- Ferguson, D. W., Berg, W. J., Sanders, J. S., Roach, P. J., Kempf, J. S., & Kienzle, M. G., (1989). Sympathoinhibitory responses to digitalis glycosides in heart failure patients. Direct evidence from sympathetic neural recordings. Circulation, 80, 65-77. https://www.ahajournals.org/doi/abs/10.1161/01.cir.80.1.65
- He, L., He, T., Farrar, S., Ji, L., Liu, T., & Ma, X. (2017). Antioxidants maintain cellular redox homeostasis by elimination of reactive oxygen species. Cellular Physiology and Biochemistry, 44, 532-553. https://doi.org/10.1159/000485089
- ITIS (2021). Integrated Taxonomic Information System – Report. Cordia myxa L., accessed 26 July 2021, https://www.itis.gov/servlet/SingleRpt/SingleRpt?search_topic=TSN&search_value=565086#null
- Jamkhande, P. G., Barde, S. R., Patwekar, S. L., & Tidke, P. S., (2013). Plant profile, phytochemistry and pharmacology of Cordia dichotoma (Indian cherry): A review. Asian Pacific Journal of Tropical Biomedicine, 3(12), 1009-1012. https://doi.org/10.1016/S2221-1691(13)60194-X
- Jasiem, T. M., Al-Mugdadi, S. F. H., Aljubory, I. S., & Latef, Q. N., (2016). Phytochemical study and antibacterial activity of crude alkaloids and mucilage of Cordia myxa in Iraq. International Journal of Pharmaceutical Sciences Review and Research, 39, 232-236.
- Juel, C., (1988). Intracellular pH recovery and lactate efflux in mouse soleus muscles stimulated in vitro: the involvement of sodium/proton exchange and a lactate carrier. Acta Physiologica Scandinavica, 132, 363-371. https://doi.org/10.1111/j.1748-1716.1988.tb08340.xKuppast, I., & Nayak, P., (2006). Wound healing activity of Cordia dichotoma Forst. f. fruits. Niscair Online Periodicals Repository, 5(2), 99-102
- Maddu, N. (2019). Chapter 20. Diseases related to types of free radicals. 18pp. In Shalaby, E. (Ed.). Antioxidants. Intech Open. https://doi.org/10.5772/intechopen.82879 https://books.google.iq/books?hl=en&lr=&id=vHH8DwAAQBAJ&oi=fnd&pg=PA369&dq=Diseases+Related+to+Types+of+Free+Radicals.&ots=ON2dCUrTsy&sig=jGxUw1GbDrxVUEOXUTO0kyIk0hQ&redir_esc=y#v=onepage&q=Diseases%20Related%20to%20Types%20of%20Free%20Radicals.&f=false
- Maughan, R., Leiper, J., & Shirreffs, S., (2013). Haematology. pp. 132-151. In: Eston, R. & Reilly, T. (Eds.). Kinanthropometry and exercise physiology laboratory manual: Tests, procedures and data. Routledge, 376pp. https://books.google.com.bn/books?id=RA6PAgAAQBAJ
- Okwu, D. E., (2001). Evaluation of the chemical composition of indigenous spices and flavouring agents. Global Journal of Pure and Applied Sciences, 7, 455-459. https://doi.org/10.4314/gjpas.v7i3.16293
- Orhan, I. E., (2012). Biotechnological Production of plant Secondary Metabolites. Bentham Science publishers. https://doi.org/10.2174/97816080511441120101
- Pandey, B., Deshpande, B., Singh, S., & Chandrakar, V., (2014). Estimation of elemental contents of Cordia myxa and its antimicrobial activity against various pathogenic microorganisms. Indian Journal of Scientific Research, 4, 39-44.
- Saki, J., Khademvatan, S., Pazyar, N., Eskandari, A., Tamoradi, A., & Nazari, P., (2015). In Vitro activity of cordia myxa mucilage extract against Leishmania major and L. infantum promastigotes. Jundishapur Journal of Microbiology, 8(3), e59827. https://doi.org/10.5812/jjm.19640
- Sales-Campos, H., Reis de Souza, P., Crema Peghini, B., Santana da Silva, J., & Ribeiro Cardoso, C., (2013). An overview of the modulatory effects of oleic acid in health and disease, Mini Reviews in Medicinal Chemistry, 13(2), 201-210. https://www.ingentaconnect.com/content/ben/mrmc/2013/00000013/00000002/art00003
- Sanon, S., Gansane, A., Ouattara, L. P., Traore, A., Ouedraogo, I. N., Tiono, A., Taramelli, D., Basilico, N., & Sirima, S. B., (2013). In vitro antiplasmodial and cytotoxic properties of some medicinal plants from western Burkina Faso. The African Journal of Laboratory Medicine, 2, a81. https://doi.org/10.4102/ajlm.v2i1.81
- Saranya, R., Thirumalai, T., Hemalatha, M., Balaji, R., & David, E., (2013). Pharmacognosy of Enicostemma littorale: A review. Asian Pacific Journal of Tropical Biomedicine, 3, 79-84. https://doi.org/10.1016/S2221-1691(13)60028-3
- Schmelzer, G., & Gurib-Fakim, A., (2008). Medicinal plants. 189-191 In Prota. Bakhuys Publishers, Leiden. 790pp. https://books.google.iq/books?hlMedicinal+plants&ots=QwHxqCYcK-&sig
- Souri, E., Amin, G., Farsam, H., & Barazandeh Tehrani, M., (2008). Screening of antioxidant activity and phenolic content of 24 medicinal plant extracts. Journal of Pharmaceutical Science Daru, 16, 83-87. https://www.sid.ir/en/Journal/ViewPaper.aspx?ID=109689
- Sparg, S. G., Light, M. E., & van Staden, J. (2004). Biological activities and distribution of plant saponins. Journal of Ethnopharmacology, 94, 219-243. https://doi.org/10.1016/j.jep.2004.05.016
- Tanner, J. M., Whitehouse, R. H., Hughes, P. C. R., & Carter, B. S., (1976). Relative importance of growth hormone and sex steroids for the growth at puberty of trunk length, limb length, and muscle width in growth hormone-deficient children. Journal of Pediatrics, 89, 1000-1008. https://doi.org/10.1016/S0022-3476(76)80620-8
- Tian, S., Liu, F., Zhang, X., & Upur, H., (2014). Phytochemical composition and antioxidant capacity of Cordia dichotoma seeds. Pakistan Journal of Pharmaceutical Sciences, 27(5), 1123-1129. https://pubmed.ncbi.nlm.nih.gov/25176355
- Valko, M., Leibfritz, D., Moncol, J., Cronin, M. T., Mazur, M., & Telser, J. (2007). Free radicals and antioxidants in normal physiological functions and human disease. International Journal of Biochemistry & Cell Biology, 39, 44-84. https://doi.org/10.1016/j.biocel.2006.07.001
- Vaughan, R. S., (1991). Potassium in the perioperative period. BJA: British Journal of Anaesthesia, 67, 194-200. https://doi.org/10.1093/bja/67.2.194
- Yang, Z. H., Lien, P. J., Huang, W. S., Surampalli, R.Y., & Kao, C.; M. (2017). Development of the risk assessment and management strategies for TPH-contaminated sites using TPH fraction methods. Journal of Hazardous, Toxic, and Radioactive Waste, 21, D4015003-10. https://doi.org/10.1061/(ASCE)HZ.2153-5515.0000290
References
Abdallah, I. Z., Khattab, A., & Heeba, H., (2011). Gastroprotective effect of Cordia myxa L. fruit extract against indomethacin-induced gastric ulceration in rats, Life Science Journal, 8(3), 433-445.
Abdel-Aleem, E. R., Attia, E. Z., Farag, F. F., Samy, M. N., & Desoukey, S. Y. (2019). Total phenolic and flavonoid contents and antioxidant, anti-inflammatory, analgesic, antipyretic and antidiabetic activities of Cordia myxa L. leaves. Clinical Phytoscience, 5, 29. https://doi.org/10.1186/s40816-019-0125-z
Aberoumand, A., (2011). Preliminary evaluation of some phytochemical and nutrients constituents of Iranian Cordia myxa fruits, International Journal of Agricultural and Food Science. 1(2), 3033. https://www.semanticscholar.org/paper/Preliminary-Evaluation-of-Some-Phytochemical-and-of-Aberoumand/c84ddb97518ee231a07e7489efe704d95fae68bb
Aberoumand, A., Deokule, S. S., (2008). Comparison of phenolic compounds of some edible plants of Iran and India. Pakistan Journal of Nutrition, 7, 582-585. https://doi.org/10.3923/pjn.2008.582.585
Aberoumand, A., & Deokule, S. S. (2010). Screening of some nutrients and anti-nutrients components in some plant foods of Iran and India. Journal of Agricultural Technology, 6, 777-781.
Aimey, Z., Goldson-Barnaby, A, & Bailey, D., (2020). A review of Cordia species found in the Caribbean: Cordia obliqua Willd, Cordia dichotoma G. Forst. and Cordia collococca L. International Journal of Fruit Science, 20, S884-S893. https://doi.org/10.1080/15538362.2020.1772181
Al-Hamdani, M. S., & Al-Faraji, A. S., (2017). Evaluation of inhibitory activity of Cordia myxa fruit extract on microorganisms that causes spoilage of food and its role in the treatment of certain disease states. Journal of Biology, Agriculture and Healthcare, 7(2), 43-49.
Ali, K. A. (2008). Study of effect of alcoholic extract of fruit of Cordia myxa in total count and differential count of white blood cells in rats. Al-Qadisyia Journal of Veterinary Medicine Sciences, 7(2), 7, 21-24. https://qmeds.iraqjournals.com/article_33763.html
Aljeboury, G. H. (2021). Anti-Inflammatory effect of Cordia myxa extract on bacteria that Infected wounds in rats as a model for human. Annals of the Romanian Society for Cell Biology, 25(4), 16040-16045. https://www.annalsofrscb.ro/index.php/journal/article/view/5345
Al-Musayeib, N., Perveen, S., Fatima, I., Nasir, M., & Hussain, A., (2011). Molecules Antioxidant, Anti-lycation and Anti-inflammatory activities of phenolic constituents from Cordia sinensis. Molecules, 16, 10214-10226. https://doi.org/10.3390/molecules161210214
Al-Snafi, A. E., (2016). The Pharmacological and therapeutic importance of Cordia myxa- A review. IOSR Journal of Pharmacy, 6, 4757.
Arbonnier, M., (2000). [Trees, shrubs and lianas of the dry zones of West Africa France]. Montpellier: CIRAD; MNHN. 544pp. (In French) http://publications.cirad.fr/une_notice.php?dk=476380
Ayoub, Z., & Mehta, A. (2018). Medicinal plants as potential source of antioxidant agents: a review. Asian Journal of Pharmaceutical and Clinical Research, 11(6), 50-56. http://dx.doi.org/10.22159/ajpcr.2018.v11i6.24725
Anand, U., Jacobo-Herrera, N., Altemimi, A., & Lakhssassi, N. (2019). A comprehensive review on medicinal plants as antimicrobial therapeutics: Potential avenues of biocompatible drug discovery. Metabolites, 9(11), 258. https://doi.org/10.3390/metabo9110258
Ferguson, D. W., Berg, W. J., Sanders, J. S., Roach, P. J., Kempf, J. S., & Kienzle, M. G., (1989). Sympathoinhibitory responses to digitalis glycosides in heart failure patients. Direct evidence from sympathetic neural recordings. Circulation, 80, 65-77. https://www.ahajournals.org/doi/abs/10.1161/01.cir.80.1.65
He, L., He, T., Farrar, S., Ji, L., Liu, T., & Ma, X. (2017). Antioxidants maintain cellular redox homeostasis by elimination of reactive oxygen species. Cellular Physiology and Biochemistry, 44, 532-553. https://doi.org/10.1159/000485089
ITIS (2021). Integrated Taxonomic Information System – Report. Cordia myxa L., accessed 26 July 2021, https://www.itis.gov/servlet/SingleRpt/SingleRpt?search_topic=TSN&search_value=565086#null
Jamkhande, P. G., Barde, S. R., Patwekar, S. L., & Tidke, P. S., (2013). Plant profile, phytochemistry and pharmacology of Cordia dichotoma (Indian cherry): A review. Asian Pacific Journal of Tropical Biomedicine, 3(12), 1009-1012. https://doi.org/10.1016/S2221-1691(13)60194-X
Jasiem, T. M., Al-Mugdadi, S. F. H., Aljubory, I. S., & Latef, Q. N., (2016). Phytochemical study and antibacterial activity of crude alkaloids and mucilage of Cordia myxa in Iraq. International Journal of Pharmaceutical Sciences Review and Research, 39, 232-236.
Juel, C., (1988). Intracellular pH recovery and lactate efflux in mouse soleus muscles stimulated in vitro: the involvement of sodium/proton exchange and a lactate carrier. Acta Physiologica Scandinavica, 132, 363-371. https://doi.org/10.1111/j.1748-1716.1988.tb08340.xKuppast, I., & Nayak, P., (2006). Wound healing activity of Cordia dichotoma Forst. f. fruits. Niscair Online Periodicals Repository, 5(2), 99-102
Maddu, N. (2019). Chapter 20. Diseases related to types of free radicals. 18pp. In Shalaby, E. (Ed.). Antioxidants. Intech Open. https://doi.org/10.5772/intechopen.82879 https://books.google.iq/books?hl=en&lr=&id=vHH8DwAAQBAJ&oi=fnd&pg=PA369&dq=Diseases+Related+to+Types+of+Free+Radicals.&ots=ON2dCUrTsy&sig=jGxUw1GbDrxVUEOXUTO0kyIk0hQ&redir_esc=y#v=onepage&q=Diseases%20Related%20to%20Types%20of%20Free%20Radicals.&f=false
Maughan, R., Leiper, J., & Shirreffs, S., (2013). Haematology. pp. 132-151. In: Eston, R. & Reilly, T. (Eds.). Kinanthropometry and exercise physiology laboratory manual: Tests, procedures and data. Routledge, 376pp. https://books.google.com.bn/books?id=RA6PAgAAQBAJ
Okwu, D. E., (2001). Evaluation of the chemical composition of indigenous spices and flavouring agents. Global Journal of Pure and Applied Sciences, 7, 455-459. https://doi.org/10.4314/gjpas.v7i3.16293
Orhan, I. E., (2012). Biotechnological Production of plant Secondary Metabolites. Bentham Science publishers. https://doi.org/10.2174/97816080511441120101
Pandey, B., Deshpande, B., Singh, S., & Chandrakar, V., (2014). Estimation of elemental contents of Cordia myxa and its antimicrobial activity against various pathogenic microorganisms. Indian Journal of Scientific Research, 4, 39-44.
Saki, J., Khademvatan, S., Pazyar, N., Eskandari, A., Tamoradi, A., & Nazari, P., (2015). In Vitro activity of cordia myxa mucilage extract against Leishmania major and L. infantum promastigotes. Jundishapur Journal of Microbiology, 8(3), e59827. https://doi.org/10.5812/jjm.19640
Sales-Campos, H., Reis de Souza, P., Crema Peghini, B., Santana da Silva, J., & Ribeiro Cardoso, C., (2013). An overview of the modulatory effects of oleic acid in health and disease, Mini Reviews in Medicinal Chemistry, 13(2), 201-210. https://www.ingentaconnect.com/content/ben/mrmc/2013/00000013/00000002/art00003
Sanon, S., Gansane, A., Ouattara, L. P., Traore, A., Ouedraogo, I. N., Tiono, A., Taramelli, D., Basilico, N., & Sirima, S. B., (2013). In vitro antiplasmodial and cytotoxic properties of some medicinal plants from western Burkina Faso. The African Journal of Laboratory Medicine, 2, a81. https://doi.org/10.4102/ajlm.v2i1.81
Saranya, R., Thirumalai, T., Hemalatha, M., Balaji, R., & David, E., (2013). Pharmacognosy of Enicostemma littorale: A review. Asian Pacific Journal of Tropical Biomedicine, 3, 79-84. https://doi.org/10.1016/S2221-1691(13)60028-3
Schmelzer, G., & Gurib-Fakim, A., (2008). Medicinal plants. 189-191 In Prota. Bakhuys Publishers, Leiden. 790pp. https://books.google.iq/books?hlMedicinal+plants&ots=QwHxqCYcK-&sig
Souri, E., Amin, G., Farsam, H., & Barazandeh Tehrani, M., (2008). Screening of antioxidant activity and phenolic content of 24 medicinal plant extracts. Journal of Pharmaceutical Science Daru, 16, 83-87. https://www.sid.ir/en/Journal/ViewPaper.aspx?ID=109689
Sparg, S. G., Light, M. E., & van Staden, J. (2004). Biological activities and distribution of plant saponins. Journal of Ethnopharmacology, 94, 219-243. https://doi.org/10.1016/j.jep.2004.05.016
Tanner, J. M., Whitehouse, R. H., Hughes, P. C. R., & Carter, B. S., (1976). Relative importance of growth hormone and sex steroids for the growth at puberty of trunk length, limb length, and muscle width in growth hormone-deficient children. Journal of Pediatrics, 89, 1000-1008. https://doi.org/10.1016/S0022-3476(76)80620-8
Tian, S., Liu, F., Zhang, X., & Upur, H., (2014). Phytochemical composition and antioxidant capacity of Cordia dichotoma seeds. Pakistan Journal of Pharmaceutical Sciences, 27(5), 1123-1129. https://pubmed.ncbi.nlm.nih.gov/25176355
Valko, M., Leibfritz, D., Moncol, J., Cronin, M. T., Mazur, M., & Telser, J. (2007). Free radicals and antioxidants in normal physiological functions and human disease. International Journal of Biochemistry & Cell Biology, 39, 44-84. https://doi.org/10.1016/j.biocel.2006.07.001
Vaughan, R. S., (1991). Potassium in the perioperative period. BJA: British Journal of Anaesthesia, 67, 194-200. https://doi.org/10.1093/bja/67.2.194
Yang, Z. H., Lien, P. J., Huang, W. S., Surampalli, R.Y., & Kao, C.; M. (2017). Development of the risk assessment and management strategies for TPH-contaminated sites using TPH fraction methods. Journal of Hazardous, Toxic, and Radioactive Waste, 21, D4015003-10. https://doi.org/10.1061/(ASCE)HZ.2153-5515.0000290